| Titre : | Study of the inhibitory effect of some cypress metabolites on alpha amylase | | Type de document : | document multimédia | | Auteurs : | Hanane Benbey, Auteur ; Yasmine Rafia El Houiti, Auteur ; Fatima Zahra Gueffaf, Auteur ; Khadidja Benarous, Directeur de thèse ; Abderrahmane Linani, Directeur de thèse | | Editeur : | Laghouat : Université Amar Telidji - Département de biologie | | Année de publication : | 2023 | | Importance : | 52 p. | | Accompagnement : | 1 disque optique numérique (CD-ROM) | | Note générale : | Option : Applied biochemistry | | Langues : | Anglais | | Mots-clés : | α-amylase Diabetes Cupressus sempervirens L. Molecular docking ADMET PASS Diabète | | Résumé : | Diabetes mellitus (DM) is the inability of the body to manage glucose levels, which leads to severe complications. The control of postprandial hyperglycemia is an important target in the treatment of DM. The synthetic anti-DM drugs have inevitable side effects; therefore, the investigation of natural compounds with little or no side effects as α-amylase inhibitors is of notable concern. In the present study, we predict the ability of Cupressus sempervirens L. compounds such as Cupressuflavone (Mol1), Robustaflavone (Mol2), Apigenin-4'- glucoside (Mol3), Sugiol (Mol4), Podocarpusflavone A (Mol5), apigenin-7-O-beta-Dglucopyranoside (Mol6), Hinokiflavone (Mol7), Kaempferol-3-O-rhamnoside (Mol8) as human pancreatic α-amylase inhibitors by in silico study. The molecular docking study was performed using AutoDock vina and prediction of its bioavailability and biological activity with the ADMET and PASS servers. The visualization of the molecular interactions was established in the Discovery studio software. The molecular docking results of Podocarpusflavone A and Robustaflavone revealed the best binding energies with values of -11.6 kcal/mol, -11.4 kcal/mol, and they had a good ADMET profile. These compounds might become drug candidates for drug discovery against type 2 diabetes. | | note de thèses : | Mémoire de master en sciences biologiques |
Study of the inhibitory effect of some cypress metabolites on alpha amylase [document multimédia] / Hanane Benbey, Auteur ; Yasmine Rafia El Houiti, Auteur ; Fatima Zahra Gueffaf, Auteur ; Khadidja Benarous, Directeur de thèse ; Abderrahmane Linani, Directeur de thèse . - Laghouat : Université Amar Telidji - Département de biologie, 2023 . - 52 p. + 1 disque optique numérique (CD-ROM). Option : Applied biochemistry Langues : Anglais | Mots-clés : | α-amylase Diabetes Cupressus sempervirens L. Molecular docking ADMET PASS Diabète | | Résumé : | Diabetes mellitus (DM) is the inability of the body to manage glucose levels, which leads to severe complications. The control of postprandial hyperglycemia is an important target in the treatment of DM. The synthetic anti-DM drugs have inevitable side effects; therefore, the investigation of natural compounds with little or no side effects as α-amylase inhibitors is of notable concern. In the present study, we predict the ability of Cupressus sempervirens L. compounds such as Cupressuflavone (Mol1), Robustaflavone (Mol2), Apigenin-4'- glucoside (Mol3), Sugiol (Mol4), Podocarpusflavone A (Mol5), apigenin-7-O-beta-Dglucopyranoside (Mol6), Hinokiflavone (Mol7), Kaempferol-3-O-rhamnoside (Mol8) as human pancreatic α-amylase inhibitors by in silico study. The molecular docking study was performed using AutoDock vina and prediction of its bioavailability and biological activity with the ADMET and PASS servers. The visualization of the molecular interactions was established in the Discovery studio software. The molecular docking results of Podocarpusflavone A and Robustaflavone revealed the best binding energies with values of -11.6 kcal/mol, -11.4 kcal/mol, and they had a good ADMET profile. These compounds might become drug candidates for drug discovery against type 2 diabetes. | | note de thèses : | Mémoire de master en sciences biologiques |
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Study of the inhibitory effect of some cypress metabolites on alpha amylase
