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| Titre : | Optimization of the extraction of phenolic compounds from Globularia alypum L. | | Type de document : | document multimédia | | Auteurs : | Imane Zidelmel, Auteur ; Bakhti Koribaa, Directeur de thèse | | Editeur : | Laghouat : Université Amar Telidji - Département des sciences de la matière | | Année de publication : | 2025 | | Importance : | 45 p. | | Accompagnement : | 1 disque optique numérique (CD-ROM) | | Note générale : | Option : Organic chemistry | | Langues : | Anglais | | Mots-clés : | Antioxidant activity Extraction Optimization Globularia alypum L Phenolic compounds Box behnken | | Résumé : | In this study, we extracted polyphenols of the plant Globularia alypum L using ultrasonic extraction process. The use of Response surface Methodology multivariate method by Box-Behnken design allows us to optimize three variables (temperature, time and volume of methanol). In order to obtain the best yield of Total Phenolic Compounds TPC;as well as the best antioxidants activities for both DPPH and ABTS.
The optimal TPC yield was observed at 45 °C, 20 min, and 35 mL, while maximum antioxidant activities for both DPPH and ABTS occurred near 50 °C and 25 min. A strong correlation was observed between TPC and DPPH activities, confirming the contribution of phenolic compounds to radical scavenging potential. ABTS showed a similar but slightly weaker correlation. Overall, these results highlight the importance of optimizing extraction parameters to maximize the recovery of bioactive phenolics and their associated antioxidant activities. | | note de thèses : | Mémoire de master en chimie |
Optimization of the extraction of phenolic compounds from Globularia alypum L. [document multimédia] / Imane Zidelmel, Auteur ; Bakhti Koribaa, Directeur de thèse . - Laghouat : Université Amar Telidji - Département des sciences de la matière, 2025 . - 45 p. + 1 disque optique numérique (CD-ROM). Option : Organic chemistry Langues : Anglais | Mots-clés : | Antioxidant activity Extraction Optimization Globularia alypum L Phenolic compounds Box behnken | | Résumé : | In this study, we extracted polyphenols of the plant Globularia alypum L using ultrasonic extraction process. The use of Response surface Methodology multivariate method by Box-Behnken design allows us to optimize three variables (temperature, time and volume of methanol). In order to obtain the best yield of Total Phenolic Compounds TPC;as well as the best antioxidants activities for both DPPH and ABTS.
The optimal TPC yield was observed at 45 °C, 20 min, and 35 mL, while maximum antioxidant activities for both DPPH and ABTS occurred near 50 °C and 25 min. A strong correlation was observed between TPC and DPPH activities, confirming the contribution of phenolic compounds to radical scavenging potential. ABTS showed a similar but slightly weaker correlation. Overall, these results highlight the importance of optimizing extraction parameters to maximize the recovery of bioactive phenolics and their associated antioxidant activities. | | note de thèses : | Mémoire de master en chimie |
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